Retinyl acetate is the acetate ester of retinol and it is commercially used as a vitamin A supplement. Retinyl acetate exhibits antibiotic, anti-diabetic, anti-inflammatory, and anticancer chemotherapeutic activities. Retinyl acetate modulates Ca2+ signaling in vitro and is occasionally used to improve embryo production in livestock. This compound displays antibacterial efficacy against Mycobacterium in vitro. In vivo, retinyl acetate decreases incidence of diabetes and suppresses LPS-stimulated TNF-α expression. In animal models of colorectal cancer, retinyl acetate upregulates expression of TRAIL receptors, inhibiting tumor growth and increasing survival rates.