Description
Didymin is a flavonoid glycoside found in citrus fruits that displays antioxidative and anticancer chemotherapeutic activities. In cellular and animal models of non-small cell lung cancer (NSCLC), didymin induces Fas-mediated apoptosis and delays tumor growth. Additionally, didymin downregulates PI3K, pAkt, Akt, and vimentin expression and decreases levels of CDK4, n-Myc, and cyclins B1 and D1 in vitro. In animal models of neuroblastoma, didymin decreases tumor size.
