Radicicol is an analog of benzoquinone ansamycin that inhibits HSP90, Src family kinases, and Raf. Radicicol exhibits neuroprotective, antibiotic, antifungal, anti-parasitic, and antimalarial activities. In Plasmodium, radicicol targets topoisomerase VI-B, inhibiting mitochondrial replication. Radicicol also increases survival and neurite outgrowth of neurons in chick embryos.
| Cas No. |
12772-57-5 |
|---|---|
| Purity |
≥96% |
| Formula |
C18H17ClO6 |
| Formula Wt. |
364.78 |
| Chemical Name |
8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihyroxy-14- methyl-6H-oxireno[e][2]benzoxacyclotetradecin- 6,12(7H)-dione |
| Synonym |
Monorden, Monorderne |
| Melting Point |
193.5°C |
| Solubility |
Soluble in DMSO, methanol or ethanol. |
| Appearance |
White Crystal Powder |
| Store Temp |
-20°C |
|---|---|
| Ship Temp |
Ambient |
| MSDS | |
|---|---|
| Info Sheet |
