FC 99 hydrochloride Axon 2318

FC 99 hydrochloride
Axon 2318

CAS [N.A.]

MF C15H18N2O.xHCl
MW 304.30

Purity: 98%
Soluble in water and DMSO

Description

Inhibitor of TLR3 expression and inflammatory responses induced by a synthetic dsRNA (poly(I:C)) and by exogenous IFN-α via IRF3. FC-99 suppressed the phosphorylation levels of ERK, JNK, and p38 in varying degrees without altering the total protein The ability of FC-99 to reverse TLR3 expression may account for its marked effect on the model of sepsis.

W. Gong et al. A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis. Br. J. Pharmacol. 2014, 171, 4866-4878.

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